I found the field of Pharmacology & Pharmacy very interesting. Saw the article A Triazolotriazine-Based Dual GSK-3 beta/CK-1 delta Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition published in 2019.0. Formula: C2H4N4, Reprint Addresses Federico, S (corresponding author), Univ Trieste, Dept Chem & Pharmaceut Sci, Via Licio Giorgeri 1, I-34127 Trieste, Italy.; Cavalli, A (corresponding author), Ist Italiano Tecnol, Drug Discovery & Dev D3, Via Morego 30, I-16163 Genoa, Italy.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine
Glycogen synthase kinase 3 beta (GSK-3 beta) and casein kinase 1 delta (CK-1 delta) are emerging targets for the treatment of neuroinflammatory disorders, including Parkinson’s disease. An inhibitor able to target these two kinases was developed by docking-based design. Compound 12, 3-(7-amino-5-(cyclohexylamino)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-2-yl)-2-cyanoacrylamide, showed combined inhibitory activity against GSK-3 beta and CK-1 delta [IC50(GSK-3 beta)=0.17 mu m; IC50(CK-1 delta)=0.68 mu m]. In particular, classical ATP competition was observed against CK-1 delta, and a co-crystal of compound 12 inside GSK-3 beta confirmed a covalent interaction between the cyanoacrylamide warhead and Cys199, which could help in the development of more potent covalent inhibitors of GSK-3 beta. Preliminary studies on in vitro models of Parkinson’s disease revealed that compound 12 is not cytotoxic and shows neuroprotective activity. These results encourage further investigations to validate GSK-3 beta/CK-1 delta inhibition as a possible new strategy to treat neuroinflammatory/degenerative diseases.
Formula: C2H4N4. Welcome to talk about 61-82-5, If you have any questions, you can contact Redenti, S; Marcovich, I; De Vita, T; Perez, C; De Zorzi, R; Demitri, N; Perez, DI; Bottegoni, G; Bisignano, P; Bissaro, M; Moro, S; Martinez, A; Storici, P; Spalluto, G; Cavalli, A; Federico, S or send Email.
Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
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