Synthetic Route of 7343-33-1, These common heterocyclic compound, 7343-33-1, name is 5-Bromo-1H-1,2,4-triazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a suspension of 3-bromo-1H-1,2,4-triazole (0.500 g, 3.38 mmol) and cesium carbonate (1.10 g, 3.38 mmol) in acetonitrile (6.8 mL) was added 1-(2-bromoethyl)-4- (trifluoromethoxy)benzene (0.909 g, 3.38 mmol). The reaction mixture was stirred at room temperature for 3 days. The solution was diluted with dichloromethane andwashed with water. The organic extracts were washed with brine, dried, filtered, and concentrated. Purification by flash column chromatography using 0-100percent ethyl acetate/hexanes as eluent provided the title compound as a colorless oil (0.410 g, 36percent): 1H NMR (400 MHz, CDCI3) O 7.66 (s, 1H), 7.15 (dq, J = 7.7, 1.0 Hz, 2H), 7.12 -7.04 (m, 2H), 4.39 – 4.28 (m, 2H), 3.19 (t, J = 7.0 Hz, 2H); 19 NMR (376 MHz, CDCI3)O -57.93; ESIMS m/z 337 ([M+H]).
The synthetic route of 7343-33-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; DOW AGROSCIENCES LLC; GIAMPIETRO, Natalie C.; CROUSE, Gary D.; SPARKS, Thomas C.; (131 pag.)WO2017/40060; (2017); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics