Adding a certain compound to certain chemical reactions, such as: 81581-05-7, name is Ethyl 1-(4-methoxybenzyl)-1H-1,2,3-triazole-4-carboxylate, belongs to triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 81581-05-7, SDS of cas: 81581-05-7
Example 42: 1-(4-methoxybenzyl)-1H-1,2,3-triazole-4-carboxylic acidTo a mixture of ethyl 1-(4-methoxybenzyl)-1 H-1 ,2,3-triazole-4-carboxylate (190.0 g, 0.73 mol) and MeOH/H2O (350 mL/100 mL) was added LiOH. H2O (42.0 g, 0.97 mol) in portions at 0 0C and the reaction mixture was stirred at room temperature overnight. The mixture was evaporated, the residue was diluted with water (250 mL), then extracted with Et2O (3×75 mL) to remove neutral impurities. The aqueous layer was adjusted to pH = 3-4 with cone. HCI and the precipitate was filtered to afford the title compound (160 g, 94.0%) as a white solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 1-(4-methoxybenzyl)-1H-1,2,3-triazole-4-carboxylate, and friends who are interested can also refer to it.
Reference:
Patent; PFIZER PRODUCTS INC.; WO2008/4096; (2008); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics