So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Kurosawa, Miki B.; Isshiki, Ryota; Muto, Kei; Yamaguchi, Junichiro researched the compound: 6-Methylnicotinic acid( cas:3222-47-7 ).Recommanded Product: 3222-47-7.They published the article 《Catalytic deoxygenative coupling of aromatic esters with organo-phosphorus compounds》 about this compound( cas:3222-47-7 ) in ChemRxiv. Keywords: benzyl phosphine oxide phosphonate phosphinate preparation reductive phosphorylation ester; aryl phenyl ester reduction phosphorylation secondary phosphine oxide phosphonate; reductive coupling aryl ester preparation phosphine oxide phosphonate phosphinate. We’ll tell you more about this compound (cas:3222-47-7).
We have developed a deoxygenative coupling of aromatic esters with diarylphosphine oxides/dialkyl phosphonates under palladium catalysis. Reaction of Ph aromatic esters ArCO2Ph with hydrophosphoryl compounds HP(O)R2 (R = Ph, aryl, BuO) in the presence of PdCl2/dcype and HCO2Na reductant afforded benzyl phosphine oxides, phosphonates and phosphinates ArCH2P(O)R2. In this reaction, aromatic esters can work as novel benzylation reagents to give the corresponding benzylic phosphorus compounds The key of this reaction is the use of Ph esters, an electron-rich diphosphine as a ligand, and sodium formate as a hydrogen source. Arylcarboxylic acids were also applicable in this reaction using (Boc)2O as an additive. Palladium/dcype worked as a bifunctional catalyst to activate the acyl C-O bond of the ester and to support the reduction with sodium formate.
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Reference:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics