In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Aminothiazole-Featured Pirinixic Acid Derivatives As Dual 5-Lipoxygenase and Microsomal Prostaglandin E2 Synthase-1 Inhibitors with Improved Potency and Efficiency in Vivo, published in 2013-11-27, which mentions a compound: 65705-44-4, Name is 4-(4-Bromophenyl)-5-methylthiazol-2-amine, Molecular C10H9BrN2S, Reference of 4-(4-Bromophenyl)-5-methylthiazol-2-amine.
Dual inhibition of microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO) is currently pursued as potential pharmacol. strategy for treatment of inflammation and cancer. Here we present a series of 26 novel 2-aminothiazole-featured pirinixic acid derivatives as dual 5-LO/mPGES-1 inhibitors with improved potency (exemplified by compound 2-[(4-chloro-6-{[4-(naphthalen-2-yl)-1,3-thiazol-2-yl]-amino}-pyrimidin-2-yl)-sulfanyl]-octanoic acid (I) with IC50 = 0.3 and 0.4 μM, resp.) and bioactivity in vivo. Computational anal. presumes binding sites of I at the tip of the 5-LO catalytic domain and within a subpocket of the mPGES-1 active site. Compound I (10 μM) hardly suppressed cyclooxygenase (COX)-1/2 activities, failed to inhibit 12/15-LOs, and is devoid of radical scavenger properties. Finally, compound I reduced vascular permeability and inflammatory cell infiltration in a zymosan-induced mouse peritonitis model accompanied by impaired levels of cysteinyl-leukotrienes and prostaglandin E2. Together, 2-aminothiazole-featured pirinixic acids represent potent dual 5-LO/mPGES-1 inhibitors with an attractive pharmacol. profile as anti-inflammatory drugs.
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Reference:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics