Adding a certain compound to certain chemical reactions, such as: 103755-58-4, name is (1-Phenyl-1H-1,2,3-triazol-4-yl)methanol, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 103755-58-4, name: (1-Phenyl-1H-1,2,3-triazol-4-yl)methanol
Methyl iodide (7.34g, 3.24mL, 51.72mmol, 6equiv.) was added to acetonitrile (10mL) solution of triazole 1 (1.5g, 8.62mmol, 1equiv.) and heated in a teflon lined sealed steel vessel at 80C for 36h. After completion of reaction, solvent was removed under vacuo and washed with ethyl acetate (5¡Á10mL) to give pale yellow crystalline solid in (2.25g) 83% yield. Mp: 140-142C; IR (KBr): 3316 (nuOH), 1597, 1077cm-1; 1H NMR (400MHz, CDCl3) delta: 9.35 (s, 1H), 7.92-7.90 (m, 2H), 7.65-7.63 (m, 3H), 5.15 (d, 2H, J=6Hz), 5.00 (t, 1H, J=6Hz), 4.51 (s, 3H); 13C NMR (100MHz, CDCl3) delta: 145.0, 134.7, 132.2, 130.7, 128.4, 121.7, 53.0 (-CH2-OH), 40.0 (-CH3-N); HRMS (ESI-MS) calcd for C10H13N3O [M+H]+ 191.1059, found 191.1067.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, (1-Phenyl-1H-1,2,3-triazol-4-yl)methanol, and friends who are interested can also refer to it.
Reference:
Short Survey; Saravanakumar, Rajendran; Ramkumar, Venkatachalam; Sankararaman, Sethuraman; Journal of Organometallic Chemistry; vol. 736; (2013); p. 36 – 41;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics