Adding a certain compound to certain chemical reactions, such as: 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16681-70-2, Recommanded Product: 1H-[1,2,3]Triazole-4-carboxylic acid
[0839] lH-1,2,3-triazole-4-carboxylic acid (3.8 mg, 34f.tmol)was combined withHATU (12.9 mg, 34 flillOl) inDMF(2 mL) and stirred at room temperature for 15 minutes. Compound3 (13 mg, 31 f.tmol) and DIPEA (16 f.LL, 92 flillOl) werethen added. The solution was stirred at room temperature for15 minutes, at which time LCMS showed reaction completion. The solvent was removed in vacuo and the crude residuewas purified by reverse phase chromatography to yield Compoundb (15 mg) as a TFA salt. MS m/z [M+Ht calc’d forC25H29CIFN50 4 , 518.19. found 518.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-[1,2,3]Triazole-4-carboxylic acid, and friends who are interested can also refer to it.
Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; Fleury, Melissa; Beausoliel, Anne-Marie; Hughes, Adam D.; Long, Daniel D.; Wilton, Donna A.A.; US2015/210690; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics