Adding a certain compound to certain chemical reactions, such as: 4923-01-7, name is 5-Methyl-4H-1,2,4-triazol-3-amine, belongs to triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4923-01-7, Computed Properties of C3H6N4
A mixture of methyl 3-oxo-2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1 -yl)butanoate (70A) (40 mg, 0.107 mmol),Ts-OH (3.04 mg, 0.016 mmol) and 3-methyl-1H-1,2,4-triazol-5-amine (15.68 mg, 0.160 mmol) in toluene (1 mL) was heated at 120 C for overnight. The reaction mixture was cooled and solvent was removed to give a residue, which was purified by HPLC to give desired product. 1H NMR (400 MHz, Methanol-d4) delta 7.24 – 7.15 (m, 2H), 7.12 – 6.95 (m, 2H), 4.39 (s, 1 H), 3.96 – 3.76 (m, 1 H), 3.74 – 3.53 (m, 2H), 2.98 – 2.77 (m, 1 H), 2.51 (s, 3H), 2.43 (s, 3H), 2.24- 2.06 (m, 2H), 2.06- 1.89 (m, 1H), 1.85- 1.60 (m, 1H). Method 1: RT= 1.11 min.; M/Z(M+H) = 424.1.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Methyl-4H-1,2,4-triazol-3-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NOVARTIS AG; CHIANELLI, Donatella; GIBNEY, Michael; LERARIO, Isabelle K.; LIANG, Fang; LIU, Xiaodong; MOLTENI, Valentina; NAGLE, Advait Suresh; SMITH, Jeffrey M.; SUPEK, Frantisek; XIE, Yongping; YEH, Vince; (64 pag.)WO2018/229683; (2018); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics