Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 584-13-4, name is 4H-1,2,4-Triazol-4-amine, A new synthetic method of this compound is introduced below., SDS of cas: 584-13-4
5-(4H-l,2,4~Triazol-4-yIaraino)-4t-fluorobiphenyl-2-carbonitrile (CAB06062)To a solution of 4/f-l ,2,4-triazol-4-amme (1.711 g, 20.35 mmol) in DMSO (30 mL) was added KOtBu (2.28 g, 20.35 mmol). The mixture was stirred for 0.5 h at room temperature before CAB06058 (2.19 g, 10.17 mmol) was added and stirring was continued for 1 hour. The mixture was poured into crushed ice and neutralized with 2M KHSO4 solution. The precipitate was filtered off, washed with water and reciystallised from ElOAc/n-hexane to afford CAB06062 (2,07 g, 73%) as a light yellow crystalline solid. Mp- 231-234 0C; 1H NMR (400 MHz, DMSO-rfbeta) delta 6.50 (d, .1 = 2 4 Hz3 IH), 6.58 (dd, J = 8.6, 2.4 Hz, IH)3 7.32-738 (m. 2H), 7.51-7.58 (m, 2H), 7.80 (d, J = 8.6 Hz, IH), 8.86 (s, 2H)5 1032 (s, IH); LRMS (ES+): mfz 280.1 (100%, [M+H]+); HRMS (ES+) calcd for Ci5HnFN5 [M+H]+: 280.0993, found 280.0982; Anal Calcd for C15Hj0FN5: C, 64.51 ; H, 3.61; N, 25.08 Found C, 64.4; H3 3.57; N, 24.8.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; STERIX LIMITED; WOO, Lok Wai Lawrence; BUBERT, Christian; WOOD, Paul Michael; PUTEY, Aurelien; PUROHIT, Atul; POTTER, Barry Victor Lloyd; WO2011/23989; (2011); A1;,
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