Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 252742-72-6, name is 3-(Chloromethyl)-1H-1,2,4-triazol-5(4H)-one, A new synthetic method of this compound is introduced below., Safety of 3-(Chloromethyl)-1H-1,2,4-triazol-5(4H)-one
A mixture of 5-(chloromethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one (30, 2.00 g, 15.0 mmol, synthesized by the method of Cowden et al. 59), (4-bromophenyl)methanethiol (3.04 g, 15.0 mmol), and K2CO3 (2.48 g, 18.0 mmol) in DMF (40 mL) was stirred at room temperature for 12 h. After H2O was added to the reaction mixture, the precipitated solid was collected and washed with H2O and diethyl ether to give the title compound as a white powder (3.97 g, 13.2 mmol, 88percent). 1H NMR (300 MHz, DMSO-d6) d 3.36 (2H, s), 3.70 (2H, s), 7.28 (2H, d, J = 8.3 Hz), 7.52 (2H, d, J = 8.3 Hz), 11.29 (1H, br s), 11.39 (1H, br s).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Nara, Hiroshi; Sato, Kenjiro; Kaieda, Akira; Oki, Hideyuki; Kuno, Haruhiko; Santou, Takashi; Kanzaki, Naoyuki; Terauchi, Jun; Uchikawa, Osamu; Kori, Masakuni; Bioorganic and Medicinal Chemistry; vol. 24; 23; (2016); p. 6149 – 6165;,
1,2,3-Triazole – Wikipedia,
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