Electric Literature of 1001401-62-2, The chemical industry reduces the impact on the environment during synthesis 1001401-62-2, name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid, I believe this compound will play a more active role in future production and life.
To a solution of 2-(2H-l,2,3-triazol-2-yl)benzoic acid (324 mg, 1.7 mmol) in DCM (2 mL) was added SOCI2 (601 mg, 5.1 mmol) at RT. The resulting mixture was stirred at 50 C for 2 h. After cooling to RT, the mixture was concentrated in vacuo. To a solution of the product from Step 2 (300 mg, 1.7 mmol) and the above residue in DCM (6 mL) at 0 C was added Epsilon Nu (515 mg, 5.1 mmol) slowly. The resulting mixture was stirred at 0 C for 20 mins, then quenched with water (10 mL) and extracted with DCM (20 mL x 3). The combined organic layers were dried over Na2SC>4, filtered, and concentrated in vacuo. The residue was purified by prep-TLC (EtOAc) to give the title compound as a oil. LRMS m/z (M+H) 347.1 found, 347.2 required.
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Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; LIVERTON, Nigel; LUO, Yunfu; (85 pag.)WO2016/100156; (2016); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics