New discoveries in chemical research and development in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world.16681-72-4, name is 5-Bromo-1-methyl-1H-1,2,4-triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. name: 5-Bromo-1-methyl-1H-1,2,4-triazole
To a stirred solution of tert-butyl 4-[(2-{[6-(4,4,5,5-tetramethyl- 1 ,3,2-dioxaborolan-2-yl)-1 Hbenzimidazol-2-yl]am ino}pyridin-4-yl)methyl]piperazine-1 -carboxylate (800 mg, 1.50 mmol) in 1-propanol (17 mL) was added a potassium carbonate solution (2.2 mL, 2.0 M, 4.5 mmol), 5-bromo-1-methyl-1H-1,2,4-triazole (375 mg, 97 % purity, 2.25 mmol), triphenylphosphine (39.3 mg, 150 pmol) and PdCI2(PPh3)2 (105 mg, 150 pmol). The mixture was heated to 110C in a sealed tube for 14 h. Water was added and the mixture was extracted with dichloromethane. The organic phase was dried (sodium sulfate), filtered and the solvent was removed in vacuum. Aminophase-silicagel chromatography followed by silicagel chromatography gave196.0 mg (26 % yield) of the title compound.LC-MS (Method 2): R = 1.12 mm; MS (ESIpos): m/z = 490 [M+H]1HNMR (400 MHz, DMSO-d6) [ppm]: 1.066 (15.61), 1.396 (16.00), 1.988 (0.58), 2.361(1.27), 3.506 (1.73), 3.939 (2.53), 3.995 (1.60), 5.759 (2.17), 7.954 (1.49), 8.269 (0.80).
We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 5-Bromo-1-methyl-1H-1,2,4-triazole ,and how the biochemistry of the body works.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; SCHULZE, Volker; HEINRICH, Tobias; PRINZ, Florian; LEFRANC, Julien; SCHROeDER, Jens; MENGEL, Anne; BONE, Wilhelm; BALINT, Joszef; WENGNER, Antje; EIS, Knut; IRLBACHER, Horst; KOPPITZ, Marcus; BOeMER, Ulf; BADER, Benjamin; BRIEM, Hans; LIENAU, Philip; CHRIST, Clara; STOeCKIGT, Detlef; HILLIG, Roman; (1256 pag.)WO2017/102091; (2017); A1;,
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