Authors Colombo, M; Masiero, S; Rosa, S; Caporali, E; Toffolatti, SL; Mizzotti, C; Tadini, L; Rossi, F; Pellegrino, S; Musetti, R; Velasco, R; Perazzolli, M; Vezzulli, S; Pesaresi, P in NATURE PORTFOLIO published article about PLASMOPARA-VITICOLA; PESTICIDE-RESIDUES; CELLULOSE SYNTHASE; RESISTANCE; MECHANISMS; PATHOGEN; EXPOSURE; DEFENSE; DOMAIN; BIOSYNTHESIS in [Colombo, Monica; Perazzolli, Michele; Vezzulli, Silvia] Fdn Edmund Mach, Res & Innovat Ctr, San Michele All Adige, Italy; [Masiero, Simona; Rosa, Stefano; Caporali, Elisabetta; Mizzotti, Chiara; Tadini, Luca; Pesaresi, Paolo] Univ Milan, Dept Biosci, Milan, Italy; [Toffolatti, Silvia Laura] Univ Milan, Dept Agr & Environm Sci DISAA, Milan, Italy; [Rossi, Fabio] Univ Milan, Ctr Study & Res Obes, Dept Med Biotechnol & Translat Med, Milan, Italy; [Pellegrino, Sara] Univ Milan, DISFARM Dept Pharmaceut Sci, Milan, Italy; [Musetti, Rita] Univ Udine, Dept Agr Food Environm & Anim Sci, Udine, Italy; [Velasco, Riccardo] CREA Res Ctr Viticulture & Enol, Conegliano, TV, Italy; [Perazzolli, Michele] Univ Trento, Ctr Agr Food Environm C3A, San Michele All Adige, Italy in 2020.0, Cited 81.0. SDS of cas: 61-82-5. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5
Grapevine (Vitis vinifera L.) is a crop of major economic importance. However, grapevine yield is guaranteed by the massive use of pesticides to counteract pathogen infections. Under temperate-humid climate conditions, downy mildew is a primary threat for viticulture. Downy mildew is caused by the biotrophic oomycete Plasmopara viticola Berl. & de Toni, which can attack grapevine green tissues. In lack of treatments and with favourable weather conditions, downy mildew can devastate up to 75% of grape cultivation in one season and weaken newly born shoots, causing serious economic losses. Nevertheless, the repeated and massive use of some fungicides can lead to environmental pollution, negative impact on non-targeted organisms, development of resistance, residual toxicity and can foster human health concerns. In this manuscript, we provide an innovative approach to obtain specific pathogen protection for plants. By using the yeast two-hybrid approach and the P. viticola cellulose synthase 2 (PvCesA2), as target enzyme, we screened a combinatorial 8 amino acid peptide library with the aim to identify interacting peptides, potentially able to inhibit PvCesa2. Here, we demonstrate that the NoPv1 peptide aptamer prevents P. viticola germ tube formation and grapevine leaf infection without affecting the growth of non-target organisms and without being toxic for human cells. Furthermore, NoPv1 is also able to counteract Phytophthora infestans growth, the causal agent of late blight in potato and tomato, possibly as a consequence of the high amino acid sequence similarity between P. viticola and P. infestans cellulose synthase enzymes.
Welcome to talk about 61-82-5, If you have any questions, you can contact Colombo, M; Masiero, S; Rosa, S; Caporali, E; Toffolatti, SL; Mizzotti, C; Tadini, L; Rossi, F; Pellegrino, S; Musetti, R; Velasco, R; Perazzolli, M; Vezzulli, S; Pesaresi, P or send Email.. SDS of cas: 61-82-5
Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics