Safety of 1H-1,2,4-Triazol-5-amine. I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Synthesis of C-beta-D-glucopyranosyl derivatives of some fused azoles for the inhibition of glycogen phosphorylase published in 2019.0, Reprint Addresses Bokor, E; Somsak, L (corresponding author), Univ Debrecen, Dept Organ Chem, POB 400, H-4002 Debrecen, Hungary.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine.
Annulated C-beta-D-glucopyranosyl heterocycles were synthesized and tested as inhibitors of glycogen phosphorylase. 2-(beta-D-Glucopyranosyl)-1H-imidazo[4,5-b] pyridine was formed by ring-closure of O-perbenzoylated C-beta-D-glucopyranosyl formic acid with 2,3-diaminopyridine in the presence of triphenylphosphite. Cyclisations of bromomethyl 2,3,4,6-tetra-O-benzoyl-beta-D-glucopyranosyl ketone with a set of 2-aminoheterocycles resulted in constitutionally reversed C-beta-D-glucopyranosyl imidazoles fused by pyridine, pyrimidine, thiazole, 1,3,4-thiadiazole, benzothiazole and benzimidazole. O-Debenzoylation of the above compounds was effected by standard transesterification to get the test compounds. The 1H-imidazo[4,5-b] pyridine proved to be a low micromolar inhibitor (K-i = 21.1 mu M) of rabbit muscle glycogen phosphorylase b, while the other heterocycles displayed weak or no inhibition against the same enzyme.
Welcome to talk about 61-82-5, If you have any questions, you can contact Szennyes, E; Bokor, E; Docsa, T; Sipos, A; Somsak, L or send Email.. Safety of 1H-1,2,4-Triazol-5-amine
Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
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