Related Products of 705-86-2, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 705-86-2, Name is 6-Pentyltetrahydro-2H-pyran-2-one, SMILES is O=C1CCCC(CCCCC)O1, belongs to Triazoles compound. In a article, author is Ben Hassen, Manel, introduce new discover of the category.
Regioselective Synthesis of Novel [1,2,4]Triazolo[1,5-a]pyridine Derivatives
Herein we report the reaction of 2-(5-aryl-4H-1,2,4-triazol-3-yl)acetonitriles 1 a,b with appropriate Michael acceptors 2-4 to give novel [1,2,4]triazolo[1,5-a]pyridines 5-8, whose antioxidant properties have been investigated. A plausible reaction mechanism, supported by DFT calculations, has been proposed to explain the total observed regioselective formation of [1,2,4]triazolo[1,5-a]pyridine derivatives depending on the type of substituents on the Michael acceptor. Triazoles are well-known agents exhibiting antimicrobial,([1]) antitumor,([2]) anti-inflammatory,([3]) antihypertensive,([4]) anticonvulsant,([5]) antiviral([6]) and analgesic([7]) biological activities. On the other hand, pyridine is the key core of heterocyclic derivatives showing a variety of pharmacological properties.([8-12]) Several studies have revealed that a combination of different bioactive molecules, having different mechanisms of action, is a current strategy affording useful therapeutic agents.([13]) This is the case of the [1,2,4]triazolo[1,5-a] pyridine heterocyclic motif,([14]) present in a number of bioactive compounds,([15]) and largely used in materials chemistry.([16]) Accordingly, diverse synthetic methods have been described for the synthesis of differently substituted [1,2,4]triazolo[1,5-a]pyridines.([17-24]) Our group has recently reported the ultrasound-promoted facile and convenient one-pot procedure for the synthesis of novel [1,2,4]triazolo[1,5-a]pyridines in short reaction times and high yields, based on the reaction of 2-(5-aryl-4H-1,2,4-triazol-3-yl)acetonitriles, malononitrile (or ethyl cyanoacetate) and aromatic aldehydes, in absolute ethanol, in the presence of IRA-400.([25])
Related Products of 705-86-2, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 705-86-2 is helpful to your research.