Highly N2-Selective Palladium-Catalyzed Arylation of 1,2,3-Triazoles was written by Ueda, Satoshi;Su, Ming-Juan;Buchwald, Stephen L.. And the article was included in Angewandte Chemie, International Edition in 2011.Application In Synthesis of 4-(2H-1,2,3-Triazol-2-yl)benzaldehyde This article mentions the following:
Exceptional levels of N2 selectivity can be obtained in the palladium-catalyzed N-arylation of simple 1,2,3-triazoles by the use of the very bulky biarylphosphine ligand I. This method enabled the first highly N2-selective arylation of 4-substituted and 4,5-unsubstituted 1,2,3-triazoles with aryl bromides, chlorides, and triflates. E.g., in presence of Pd2(dba)3, ligand I, and K3PO4, arylation of 3-(1,2,3-triazol-4-yl)pyridine (prepared from TMSN3 and 3-ethynylpyridine) with 3,5-dimethoxybromobenzene gave 86% 3-[2-(3,5-dimethoxyphenyl)-2H-1,2,3-triazol-4-yl]pyridine (II). In the experiment, the researchers used many compounds, for example, 4-(2H-1,2,3-Triazol-2-yl)benzaldehyde (cas: 179056-04-3Application In Synthesis of 4-(2H-1,2,3-Triazol-2-yl)benzaldehyde).
4-(2H-1,2,3-Triazol-2-yl)benzaldehyde (cas: 179056-04-3) belongs to triazole derivatives. The many free lone pairs in triazoles make them useful as coordination compounds, although not typically as haptic ligands. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeApplication In Synthesis of 4-(2H-1,2,3-Triazol-2-yl)benzaldehyde
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics