Wan, Zhaohua; Wang, Dan; Yang, Zixuan; Zhang, Heng; Wang, Shengchun; Lei, Aiwen published an article in 2020, the title of the article was Electrochemical oxidative C(sp3)-H azolation of lactams under mild conditions.Application In Synthesis of 4-(p-Tolyl)-1H-1,2,3-triazole And the article contains the following content:
An electrochem. oxidative direct C(sp3)-H azolation of lactams was reported under metal catalyst-free and external chem. oxidant-free conditions. This electrochem. C(sp3)-H/N-H coupling was characterized by its broad substrate scope of azoles and lactams under mild conditions at room temperature Mechanistic studies suggested that the reaction possibly involves a radical process. Moreover, the site selectivity was explained by DFT calculations More meaningfully, a gram-scale synthesis method of flow electrochem. was employed to show the scaled-up applicability of this transformation. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Application In Synthesis of 4-(p-Tolyl)-1H-1,2,3-triazole
The Article related to azole lactam electrochem oxidative azolation, azolyl lactam preparation, amide azole electrochem oxidative azolation, amido azole preparation, pyrazole urea electrochem oxidative azolation, pyrazolyl urea preparation and other aspects.Application In Synthesis of 4-(p-Tolyl)-1H-1,2,3-triazole
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics