Wang, Ban; Mccabe, Gavin E.; Parrish, Mitchell J.; Singh, Jujhar; Zeller, Matthias; Deng, Yongming published an article in 2022. The article was titled 《Organic Photoredox Catalyzed Direct Hydroamination of Ynamides with Azoles》, and you may find the article in Advanced Synthesis & Catalysis.Computed Properties of C2H3N3 The information in the text is summarized as follows:
Disclosed herein was a photoinduced selective hydroamination of ynamides with nitrogen heteroaromatic nucleophiles. By using an organocatalytic photoredox system, a direct method to construct a diverse of (Z)-α-aryl enamides I [R1 = Ph, n-hexyl, 4-MeC6H4, etc.; R2 = Me, t-Bu, Bn; R3 = Ms, Ts, Ns; Ar = pyrazol-1-yl, triazol-1-yl, (5-methyltetrazol-2-yl), etc.] from ynamides and pyrazoles, as well as triazoles, benzotriazoles, indazoles, and tetrazoles, was developed, thus providing a photocatalytically synthetic route to heterocyclic motifs common in medicinal agents. Based on the mechanistic studies, the hydroamination was postulated to operate via a mechanism in which the single-electron oxidation of ynamide and the intermediacy of an alkyne radical cation, was responsible for the observed reactivity. In addition to this study using 1H-1,2,3-Triazole, there are many other studies that have used 1H-1,2,3-Triazole(cas: 288-36-8Computed Properties of C2H3N3) was used in this study.
1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Computed Properties of C2H3N3
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics