Wang, Bao-gang published the artcileDesign, synthesis, and antifungal activity of 3-substituted triazole derivatives, Recommanded Product: 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, the publication is Dier Junyi Daxue Xuebao (2010), 31(10), 1114-1119, database is CAplus.
Several α-(2,4-difluorophenyl)bis[[[1-(phenylmethyl)-1H-1,2,3-triazol-3-yl]methyl]amino]-1H-1,2,4-triazole-1-ethanol derivatives were designed, the synthesis of the target compounds was achieved by a click reaction of a bis[alkyne] precursor with benzyl azides and the products thus obtained were confirmed by 1H-NMR and MS. The title compounds were evaluated for their activity against fungal pathogens such as Candida albicans, Cryptococcus neoformans, Candida parapsilosis, Candida tropicalis, Trichophyton rubrum, Candida krusei, Microsporum gypseum and Aspergillus fumigatus and it was discovered that several compounds possessed activity greater than that of Fluconazole or Itraconazole. Large side chains may be a disadvantage for improving the antifungal activity of the title compounds
Dier Junyi Daxue Xuebao published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C10H17N3O2, Recommanded Product: 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate.
Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics