Authors Fandzloch, M; Jedrzejewski, T; Dobrzanska, L; Esteban-Parra, GM; Wisniewska, J; Paneth, A; Paneth, P; Sitkowski, J in ROYAL SOC CHEMISTRY published article about in [Fandzloch, Marzena] Polish Acad Sci, Inst Low Temp & Struct Res, Okolna 2, PL-50422 Wroclaw, Poland; [Jedrzejewski, Tomasz] Nicolaus Copernicus Univ Torun, Fac Biol & Vet Sci, Dept Immunol, Lwowska 1, PL-87100 Torun, Poland; [Dobrzanska, Liliana; Wisniewska, Joanna] Nicolaus Copernicus Univ Torun, Fac Chem, Gagarina 7, PL-87100 Torun, Poland; [Esteban-Parra, Gines M.] Univ Granada, Dept Inorgan Chem, Avda Severo Ochoa S-N, Granada 18071, Spain; [Paneth, Agata] Med Univ Lublin, Fac Pharm, Dept Organ Chem, Chodzki 4a, PL-20093 Lublin, Poland; [Paneth, Piotr] Lodz Univ Technol, Fac Chem, Inst Appl Radiat Chem, Zeromskiego 116, PL-90924 Lodz, Poland; [Sitkowski, Jerzy] Natl Inst Med, Chelmska 30-34, PL-00725 Warsaw, Poland; [Sitkowski, Jerzy] Polish Acad Sci, Inst Organ Chem, Kasprzaka 44-52, PL-01224 Warsaw, Poland in 2021.0, Cited 91.0. Product Details of 61-82-5. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5
Three half-sandwich organometallic ruthenium(II) complexes containing purine analogs such as triazolo-pyrimidines of general formula [(eta(6)-p-cym)Ru(L)Cl-2], where p-cym represents p-cymene and L is 5,6,7-trimethyl-1,2,4-triazolo[1,5-alpyrimidine (tmtp for 1), 5,7-diethyl-1,2,4-triazolo[1,5-a]pyrimidine (detp for 2) and 5-methyl-1,2,4-triazolo(1,5-a]pyrimidin-7(4H)-one (HmtpO for 3), have been synthesized and characterized by elemental analysis, infrared, multinuclear magnetic resonance spectroscopic techniques (H-1, C-13, N-15), and single-crystal X-ray diffraction (for 1 and 2). All these complexes have been thoroughly screened for their in vitro cytotoxicity against MCF-7 and HeLa cell lines as well as L929 murine fibroblast cells, indicating [(eta(6)-p-cym)Ru(HmtpO)Cl-2] (3) as the most active representative against the HeLa cell line and simultaneously being 64-fold less toxic to normal L929 murine fibroblast cells than cisplatin. At the same time, 3 has shown antimetastatic activity comparable to NAMI-A against HeLa cells both after 24 and 48 h of treatment in a wound healing assay. in order to better understand the mechanism of anti-cancer action and differences in the cytotoxic activity of 1-3, the studies were expanded to determining their lipophilicity, the kinetic stability at pH 6.5-8, the effect on reactive oxygen species (ROS) production in HeLa cells and interactions with significant biomolecules (DNA and albumin) by using molecular docking and circular dichroism (CD) experiments. Furthermore, antiparasitic studies against L braziliensis, L. infantum and T cruzi reveal that the newly synthesized complexes 1-3 are very promising candidates which can compete with commercial antiparasitic drugs. Complex 3 in particular, on top of exhibiting high antiparasitic effect (IC50 < 1 mu M against two strains), reaches a selectivity index >1000.
Product Details of 61-82-5. Welcome to talk about 61-82-5, If you have any questions, you can contact Fandzloch, M; Jedrzejewski, T; Dobrzanska, L; Esteban-Parra, GM; Wisniewska, J; Paneth, A; Paneth, P; Sitkowski, J or send Email.
Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics