Reference of 4928-87-4, New Advances in Chemical Research in 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. 4928-87-4, name is 1,2,4-Triazole-3-carboxylic acid, molecular formula is C3H3N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
A solution of intermediate 27b (0.26 g, 0.58 mmol) in 15 ml of DMF was added EDCI (0.17 g, 0.89 mmol)(0 · 12g, 0 · 89mmo 1) After stirring and dissolving, 1H-1,2,4-triazole-3-carboxylic acid (0.55 g, 0.44 mmo 1)DIEA 0.2ml (1.17mmol), stirring at room temperature for 12h, TLC detection, the end of the reaction, the liquid spinning was crude, crude by silica gel GColumn chromatography [eluent (methanol: dichloromethane) = 50: 500 (nu: nu)] to give 0.1 g of the title compound of Example 34,Yield: 30.3%
Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms.In my other articles, you can also check out more blogs about 1,2,4-Triazole-3-carboxylic acid.
Reference:
Patent; Beijing Foreland Pharma Co., Ltd; Zhang, Xingmin; Wang, Ensi; Niu, Shengxiu; Guo, Jing; Dai, Zhuolin; Zheng, Nan; Ji, Qi; Li, Qinyan; Liang, Tie; (109 pag.)CN104411706; (2016); B;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics