Research speed reading in 2021. The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic. 956317-36-5, name is 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. name: 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid
To a solution of the acid (10.4 g, 51.2 mmol) in THF (250 mL), CDI (8.7 g, 53.7 mmol) was added. After 3.5 h, aqueous NH3 solution (174.1 g, 25% in water, 2.56 mol) was added. The biphasic mixture was stirred at room temperature for 75 mm. The pH was adjusted to pH 7 with 6 N HC1 and DCM were added. The layers were separated and the organic layer was washed with water, dried over Na2504 and the solvent was removed under reduced pressure. The residue was stirred with diethyl ether for 30 mm, filtered and washed with diethyl ether to give 7.9 g (76 %) of the primary amide.1H NMR (300 MHz, d6-dmso) oe = 8.01 (s, 2H, Htriazoiyi), 7.79 (br s, 1H, NH), 7.61 (d, J =8.1 Hz, 1H, Harom), 7.40 (d, J = 8.4 Hz, 1H, Harom), 7.38 (s, 1H, Harom), 7.32 (br s, 1H, NH),2.40 (s, 3H, CH3).13C NMR (75 MHz, d6-dmso) oe = 168.6, 138.0, 135.8, 134.6, 132.0, 130.5, 129.0, 123.8,20.0.
In conclusion, we affirm that quantitative kinetic descriptions of catalytic behavior continue to serve as an indispensable tool to navigate research efforts intended to model. Read on for other articles about 956317-36-5.
Reference:
Patent; SANDOZ AG; HOeFERL-PRANTZ, Kathrin; BARTH, Roland; RICHTER, Frank; ZUPANCIC, Borut; (126 pag.)WO2016/20403; (2016); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics