Research speed reading in 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 584-13-4, name is 4H-1,2,4-Triazol-4-amine belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 4H-1,2,4-Triazol-4-amine
3,5-bis(1-cyano-1-methylethyl) benzyl bromide obtained in Step IV (600 g, 1.965 mol) was heated with 4-amino-1,2,4-triazole (247.9 g, 2.948 mol) in isopropanol (4.5 L) for 7 to 7.5 hours at 80 C. to 85 C. The reaction mass was gradually cooled to 20 C. to 25 C. The reaction mass was stirred for 1 hour. The reaction mass was further cooled to 0 C. to 5 C., stirred for 2 hours, filtered, and washed with dichloromethane (2×500 ml). The reaction mass was sucked dry. The dried cake was further dried at 40 C. to 45 C. under vacuum to obtained 2,2′-[5-(4-amino-1,2,4-triazolium-1-ylmethyl)-1,3-phenylene]di(2-methylpropio-nitrile)bromide (497.5 g, 65.0% yield). MP-198-203 C. IR (In cm-1, KBr): 3204, 3116, 3080, 2987, 2229, 1643, 1607, 1565, 1469, 1438, 1196, 1004 H1NMR (in CDCl3,delta (ppm)]: 10.31 (1H,s),9.20 (1H,s),7.66-7.63 (3H,s),6.984 (2H,s),5.657 (2H,s),1.71 ( 12H,s). M+[309] (free base)
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 4H-1,2,4-Triazol-4-amine, in my other articles.
Reference:
Patent; Glenmark Pharmaceuticals Limited; US2006/189670; (2006); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics