I found the field of Pharmacology & Pharmacy very interesting. Saw the article A multifunctional therapeutic approach: Synthesis, biological evaluation, crystal structure and molecular docking of diversified 1H-pyrazolo[3,4-b]pyridine derivatives against Alzheimer’s disease published in 2019.0. Safety of 1H-1,2,4-Triazol-5-amine, Reprint Addresses Hoda, N (corresponding author), Jamia Millia Islamia, Dept Chem, New Delhi 110025, India.; Tiwari, M (corresponding author), Univ Delhi, Dr BR Ambedkar Ctr Biomed Res, New Delhi 110007, India.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine
2-(piperazin-1-yl)-N-(1H-pyrazolo[3,4-b]pyridin-3-yl)acetamides are described as a new class of selective and potent acetylcholinesterase (AChE) inhibitors and amyloid beta aggregation inhibitors. Formation of synthesized compounds (P1-P9) was justified via H-1 NMR, C-13 NMR, mass spectra and single crystal X-Ray diffraction study. All compounds were evaluated for their acetylcholinesterase and butyrylcholinesterase inhibitory activity, inhibition of self-mediated A beta aggregation and Cu(II)-mediated A beta aggregation. Also, docking study carried out was in concordance with in vitro results. The most potent molecule amongst the derivatives exhibited excellent anti-AChE activity (IC50=4.8 nM). Kinetic study of P3 suggested it to be a mixed type inhibitor. In vitro study revealed that all the compounds are capable of inhibiting self-induced beta-amyloid (A beta) aggregation with the highest inhibition percentage to be 81.65%. Potency of P1 and P3 to inhibit self-induced A beta(1-)(42) aggregation was ascertained by TEM analysis. Compounds were also evaluated for their A beta disaggregation, antioxidation, metal-chelation activity. (C) 2019 Elsevier Masson SAS. All rights reserved.
Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. Safety of 1H-1,2,4-Triazol-5-amine
Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics