Related Products of 16681-70-2, New Advances in Chemical Research in 2021.In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, molecular formula is C3H3N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
[0664] To a solution of 3H-[1,2,3]triazole-4-carboxylicacid (77 mg, 688 flillOl) and HATU (130 mg, 344 f.tmol) inDMF (1.5 mL) was added DIPEA (160 f.LL, 920 flillOl). Themixture was stirred at room temperature for 20 minutes, followedby the addition of Compound 11 (140 mg, 210 f.tmol).The mixture was stirred at room temperature for 20 minutes,then the reaction was quenched with 10% aqueous citric acid(15 mL) to pH 4. The mixture was extracted with EtOAc(3×20 mL ), washed with saturated aqueous NaCl (1 0 mL) anddried over MgS04 . The mixture was filtered and the filtratewas evaporated. The residue was purified by flash chromatography(10-100% hexanes/EtOAc gradient over 45 minutes).The fractions containing the desired product were combinedand evaporated. The residue was dried in vacuo at roomtemperature overnight to yield Compound 12 (70 mg). LCMS(ESI): calc. C33H33ClFN50 5 =634.1; obs. rn/z 634.2[M+Ht. Retention time 5.96 min.
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Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; Fleury, Melissa; Beausoliel, Anne-Marie; Hughes, Adam D.; Long, Daniel D.; Wilton, Donna A.A.; US2015/210690; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics