Research speed reading in 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. 288-36-8, name is 1H-1,2,3-Triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. 288-36-8
A mixture of 2-chloro-5-nitropyridine-3-carbonitrile (9.0 g, 49 mmol), 2H-[1,2,3]Triazole (3.41 mL, 58.8 mmol) and potassium carbonate (20.32 g, 147 mmol) in acetonitrile (225 mL) was stirred at 30 C. for 2 h. Water and ethyl acetate were added and the organic phase was separated, dried with MgSO4, filtered and the filtrate concentrated to afford the crude product, which was mixed with dichloromethane (30 mL) and filtered to afford pure 5-nitro-2-[1,2,3]triazol-2-yl-nicotinonitrile (8.3 g, 78.4% yield) as an orange solid. 1H NMR (300 MHz, DMSO-d6) delta 8.46 (s, 2H), 9.45 (d, J=2.5 Hz, 1H), 9.61 (d, J=2.5 Hz, 1H). LC-MS m/z 217.0 (M+H)+.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 288-36-8, and we look forward to future research findings.
Reference:
Patent; Janssen Pharmaceutica NV; Lu, Tianbao; Connolly, Peter J.; Cummings, Maxwell David; Barbay, Joseph Kent; Kreutter, Kevin D.; Wu, Tongfei; Diels, Gaston Stanislas Marcella; Thuring, Jan Willem; Philippar, Ulrike; Edwards, James Patrick; Shen, Fang; (202 pag.)US2019/381019; (2019); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics