Reference of 7170-01-6, New Advances in Chemical Research in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 7170-01-6, name is 3-Methyl-1H-1,2,4-triazole, molecular formula is C3H5N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
To a solution of 3-[5-(2-amino-pyrimidin-5-yl)-l-ieri-butyl-lH-benzimidazol-2-yl]-4- fluoro-benzonitrile (200 mg, 0.52 mmol) in DMSO (6 mL) are added 2-methyl-lH- 1,2,4- triazole (65 mg, 0.78 mmol) and K2C03 (143 mg, 1.04 mmol) at room temperature. The solution is heated at 100C for 12 hours. The solution is cooled down and extracted with EtOAc (2 x 15 mL) and H20 (20 mL). The combined organic layer is dried with MgS04 (500 mg) and filtered. The filtrate is concentrated and the residue is purified by silica gel flash column chromatography with 5% MeOH in CH2CI2 as the eluent to afford the title compound (130 mg, 56%) as a white solid. LCMS (ESMS): m/z: 450.20 (M++l)
This is the end of this tutorial post, and I hope it has helped your research about 7170-01-6!
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; CHEN, Zhidong; HAO, Ming-Hong; LIU, Weimin; LO, Ho-Yin; LOKE, Pui Leng; MAN, Chuk, Chui; MORWICK, Tina, Marie; NEMOTO, Peter, Allen; TAKAHASHI, Hidenori; TYE, Heather; WU, Lifen; WO2011/68821; (2011); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics