Electric Literature of 13273-53-5, New Advances in Chemical Research in 2021.In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 13273-53-5, name is 4-Bromo-1-methyl-1H-1,2,3-triazole, molecular formula is C3H4BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
Example 212(5a,8a)-8-(5-Bromo-3-methyl-3H-[l,2,3]triazol-4-yl)-8-hydroxy-2-(4-isopropoxy- phenyl) -2-aza-spiro [4.5] decan- 1 -oneA solution of 4-bromo-l-methyl-lH-l,2,3-triazole (108 mg) in tetrahyrofurane (5 mL) was cooled to -78C under an argon atmosphere and then treated dropwise with n- butyllitium (415 mu, 1.6 M in hexanes) over 10 minutes. The reaction mixture was stirred 15 min at -78C, then treated dropwise with 2-(4-isopropoxyphenyl)-2-aza- spiro[4.5]decane-l,8-dione (200 mg in 3 ml tetrahydrofuran, product of example 184, step 2). The mixture was stirred further 1 h at -78C then warmed slowly to RT. It was then partitioned between AcOEt and saturated aqueous NH4C1, the layers were separated, the organic layer washes with 1M aqueous HCL then brine and dried over Na2S04. The solvent was evaporated off the residue purified by flash chromatography (silica gel, gradient of methylene chloride and AcOEt) to give the title compound (102 mg, 31%) as a white solid. MS (m/e): 465.131 [MH+].
I am very proud of our efforts over the past few months and hope to 4-Bromo-1-methyl-1H-1,2,3-triazole help many people in the next few years.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; ACKERMANN, Jean; BRUGGER, Stephan; CONTE, Aurelia; HUNZIKER, Daniel; NEIDHART, Werner; NETTEKOVEN, Matthias; SCHULZ-GASCH, Tanja; WERTHEIMER, Stanley; WO2011/45292; (2011); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics