New discoveries in chemical research and development in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 7170-01-6, name is 3-Methyl-1H-1,2,4-triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C3H5N3
In a 25 ml RBF, a mixture of 5-chloro-2-fluorobenzaldehyde (505 mg, 3.09 mmol), 3-methyl-1H-1,2,4-triazole(270 mg, 3.09 mmol), Cs2CO3 (1007 mg, 3.09 mmol) in DMSO(6179 ul) was heated at 45 C for 4 hrs and stirred at rt overnight. The reaction mixture was diluted with EtOAc and washed with water. The combined organic phase was washed with brine, dried over MgSO4, filtered,concentrated and purified by flash chromatography to yield 74A as white solid product (140 mg, 20%).
If you are hungry for even more, make sure to check my other article about 7170-01-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; YANG, WU; CORTE, JAMES R; GILLIGAN, PAUL J; PINTO, DONALD J P; EWING, WILLIAM R; DILGER, ANDREW K; WANG, YUFENG; FANG, TIANAN; PABBISETTY, KUMAR B; SMITH II, LEON M; (307 pag.)JP2015/528022; (2015); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics