Research speed reading in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 815588-93-3, name is 1-Methyl-1H-1,2,4-triazole-5-carboxylic acid belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Product Details of 815588-93-3
[00178] To a stirring solution of Int-C (93 mg, 0.73 mmol) in DCM (20 mL) were added N, N-diisopropylethylamine (0.4 mL, 2.21 mmol), compound 7 (320 mg, 0.73 mmol), followed by EDCI.HC1 (211 mg, 1.10 mmol), HOBt (170 mg, 1.10 mmol) at 0 °C and stirred at RT for 16 h. After consumption of the starting material (by TLC), the reaction mixture was evaporated under reduced pressure and the obtained crude was purified by column chromatography by eluting 4percent MeOH/DCM to afford 8 (210 mg, crude) as yellow thick syrup. This compound was used directly for next step without any purification. LCMS m/z: 543.5 [M++l]
The catalyzed pathway has a lower Ea, but the net change in energy that results from the reaction is not affected by the presence of a catalyst. In my other articles, you can also check out more blogs about 815588-93-3
Reference:
Patent; NAUREX, INC.; LOWE, John, A.; KHAN, M., Amin; WO2014/120800; (2014); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics