Reference of 41253-21-8, New Advances in Chemical Research in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 41253-21-8, name is Sodium 1,2,4-triazol-1-ide, molecular formula is C2H2N3Na, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
(4) Synthesis of 5-(4-chlorobenzyl)-2,2-bis-methoxymethoxymethyl-1-[1,2,4]triazol-1-ylmethylcyclopentanol (Compound (XXIV), G2=CH2OCH3, Ym=4-Cl, A=N)[1,2,4]-Triazole sodium salt (526 mg, 5.78 mmol) was dissolved in NMP (3 ml), and heated to an internal temperature of 115 degrees C. To this, 1 ml of a solution of 5-chlorobenzyl-2,2-bis-methoxymethoxymethyl-cyclopentanone (Compound No. (Compound (XXII), G2=CH2OCH3, Ym=4-Cl) 1.374g (3.85 mmol) in NMP was added. To this solution, sodium t-butoxide 333mg (3.47 mmol) and TMSOB 1.193 g (6.87 mmol) were added in portions while conducting the reaction at 115 degrees C for 5 hours. After completion of the reaction, the reaction solution was cooled to 35 degrees C, combined with 15 ml of water, and extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous sodium sulfate. The solvent was distilled away and the residue was subjected to silica gel column chromatography (eluent; ethyl acetate) for purification to obtain the desired substance. Product: 680.2 mgYield: 40.2 %Description: Colorless viscous liquid1H-NMR (CDCl3) delta:1.47-1.56 (1 H, m), 1.60-1.80 (2 H, m), 1.73-1.83 (1 H, m), 2.17 (1 H, dd, J = 13.2, 4.0 Hz), 2.22-2.31 (1 H, m), 2.44 (1 H, dd, J = 13.2, 10.3 Hz), 3.31 (3 H, s), 3.33 (1 H, d, J = 9.7 Hz), 3.38 (3 H, s), 3.46 (1 H, d, J = 9.7 Hz), 3.59 (2 H, s), 4.32 (1 H, d, J = 14.2 Hz), 4.41 (1 H, s), 4.45 (1 H, d, J = 6.4 Hz), 4.48 (1 H, d, J = 6.4 Hz), 4.54 (1 H, d, J = 14.2 Hz), 4.64 (2 H, s), 7.04 (2 H, d, J = 8.4 Hz), 7.21 (2 H, d, J = 8.4 Hz), 7.95 (1 H, s), 8.24 (1 H, s).
Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms.In my other articles, you can also check out more blogs about Sodium 1,2,4-triazol-1-ide.
Reference:
Patent; KUREHA CORPORATION; ARAKI, Nobuyuki; YAMAZAKI, Toru; KUSANO, Nobuyuki; IMAI, Eiyu; KANNO, Hisashi; MORI, Masaru; MIYAKE, Taiji; WO2011/70771; (2011); A1;,
1,2,3-Triazole – Wikipedia,
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