What unique challenges do researchers face in 1H-1,2,4-Triazol-5-amine

Quality Control of 1H-1,2,4-Triazol-5-amine. Welcome to talk about 61-82-5, If you have any questions, you can contact Ulomskiy, EN; Ivanova, AV; Gorbunov, EB; Esaulkova, IL; Slita, AV; Sinegubova, EO; Voinkov, EK; Drokin, RA; Butorin, II; Gazizullina, ER; Gerasimova, EL; Zarubaev, VV; Rusinov, VL or send Email.

I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Synthesis and biological evaluation of 6-nitro-1,2,4-triazoloazines containing polyphenol fragments possessing antioxidant and antiviral activity published in 2020.0. Quality Control of 1H-1,2,4-Triazol-5-amine, Reprint Addresses Zarubaev, VV (corresponding author), Pasteur Inst Epidemiol & Microbiol, 14 Mira St, St Petersburg 197101, Russia.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Stable sigma-adducts of azolo[5,1-c]triazines and azolo[1,5-a]pyrimidines with different polyphenols were synthesized and their antioxidant and antiviral activity were investigated. Their affinity to viral hemagglutinin was assessed using molecular modelling. The phloroglucinol-modified azolo-azines possessed the highest virus-inhibiting activity. According to the results of the study of antioxidant properties of compounds, the most promising ones exhibiting highest antioxidant capacity were adducts containing in their structure pyrogallol and catechol residues and 6-nitro-triazolotriazin-7-ol scaffold. No correlation between antioxidant and virus-inhibiting activity of compounds studied was detected. The most active compounds demonstrated the ability to prevent binding of viral hemagglutinin with cellular receptor as shown in hemagglutination inhibition assay. Our results demonstrate that polyphenol-modified azolo-azines are prospective for further optimization as potential antivirals and that their action is directed against viral hemagglutinin.

Quality Control of 1H-1,2,4-Triazol-5-amine. Welcome to talk about 61-82-5, If you have any questions, you can contact Ulomskiy, EN; Ivanova, AV; Gorbunov, EB; Esaulkova, IL; Slita, AV; Sinegubova, EO; Voinkov, EK; Drokin, RA; Butorin, II; Gazizullina, ER; Gerasimova, EL; Zarubaev, VV; Rusinov, VL or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics