Srinivasulu, Vunnam; Reddy, Amarnath; Mazitschek, Ralph; Lukens, Amanda K.; Wirth, Dyann F.; Li, Liang; Naumov, Pance; O’Connor, Matthew John; Al-Tel, Taleb H. published the article 《Intramolecular Diaza-Diels-Alder Protocol: A New Diastereoselective and Modular One-Step Synthesis of Constrained Polycyclic Frameworks》. Keywords: diastereoselective modular polycyclic benzopyran benzoxepine preparation antimalarial activity SAR; acid mediated diaza Diels Alder reaction benzaldehyde aminoazine; antimalarial activity; cycloaddition; polycycles; structure-activity relationships; synthesis design.They researched the compound: 4-(4-Bromophenyl)-5-methylthiazol-2-amine( cas:65705-44-4 ).Safety of 4-(4-Bromophenyl)-5-methylthiazol-2-amine. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:65705-44-4) here.
Phenotype-based screening of diverse compound collections generated by privileged substructure-based diversity-oriented synthesis (pDOS) is considered one of the prominent approaches in the discovery of novel drug leads. However, one key challenge that remains is the development of efficient and modular synthetic routes toward the facile access of privileged small-mol. libraries with skeletal and stereochem. complexity and drug-like properties. In this regard, a novel and diverse one-pot procedure for the diastereoselective synthesis of privileged polycyclic benzopyrans and benzoxepines is described herein. These unexplored chemotypes were accessed by utilizing an acid-mediated diaza-Diels-Alder reaction of 2-allyloxy- and/or homoallyloxy benzaldehyde with 2-aminoazine building blocks. Profiling of representative analogs against blood-stage Plasmodium falciparum parasites identified three lead candidates with low micromolar antimalarial activity.
As far as I know, this compound(65705-44-4)Safety of 4-(4-Bromophenyl)-5-methylthiazol-2-amine can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics