New discoveries in chemical research and development in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 1001401-62-2, name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C9H7N3O2
A solution of (R)-tert-butyl 5-methyl-l,4-diazepane-l-carboxylate Int A (2.50 g, 11.7 mmol) in DMF (50 mL) was treated with Int H (2.21 g, 11.7 mmol), HATU (4.47 g, 11.8 mmol), and DIEA (4.89 ml, 28.0 mmol). The reaction was stirred at room temperature overnight, then diluted with saturated, aqueous NH4CI. The solution was extracted with EtOAc (2x) and the organics were subsequently washed with brine, then with water, then with brine again, dried over MgS04, filtered, and concentrated. The crude material was purified by silica gel gradient chromatography (0-60% ethyl acetate in hexanes), providing 1-1 as an oil. LRMS m/z (M+H) 386.2 found, 386.2 required.
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Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; REGER, Thomas, S.; SKUDLAREK, Jason, W.; (0 pag.)WO2016/85784; (2016); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics