Research speed reading in 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 138479-53-5, name is 2-[1,2,4]Triazol-1-yl-benzaldehyde belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 138479-53-5
Example 19: {2-Amino-5-[l-tert-butyl-2-(2-l,2,4-triazol-l-yl-phenyl)-lH- benzimidazol-5-yl]-pyridin-3-yl}-methanol To a solution of [2-amino-5-(3-amino-4-ieri-butylamino-phenyl)-pyridin-3-yl] -methanol (100 mg, 0.35 mmol) in DMF (5 mL) is added 2-[l,2,4]-triazol-l-yl-benzaldehyde (73 mg, 0.42 mmol) at room temperature. Oxone (215 mg, 0.35 mmol) in H20 (1 mL) is added and the solution is stirred for 4 hours. Saturated sodium thiosulfate solution (5 mL) is added and the mixture is extracted with EtOAc (3 x 10 mL) and H20 (10 mL). The combined organic layer is dried with MgS04 and is filtered. The filtrate is concentrated and the residue is purified by silica gel flash column chromatography eluting with 10% MeOH in CH2C12 to afford the title compound (16 mg, 10%) as a pale brown foam. LCMS (ESMS): m/z 440.20 (M++l)
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 2-[1,2,4]Triazol-1-yl-benzaldehyde, in my other articles.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; CHEN, Zhidong; HAO, Ming-Hong; LIU, Weimin; LO, Ho-Yin; LOKE, Pui Leng; MAN, Chuk, Chui; MORWICK, Tina, Marie; NEMOTO, Peter, Allen; TAKAHASHI, Hidenori; TYE, Heather; WU, Lifen; WO2011/68821; (2011); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics