An article Additional Value of 18F-FDOPA Amino Acid Analog Radiotracer to Irradiation Planning Process of Patients With Glioblastoma Multiforme WOS:000674593900001 published article about RADIOTHERAPY PLUS CONCOMITANT; TARGET DELINEATION; ADJUVANT TEMOZOLOMIDE; C-11-METHIONINE PET; BRAIN; RADIATION; GLIOMAS; DIAGNOSIS; THERAPY; FAILURE in [Sipos, David; Laszlo, Zoltan; Kovacs, Peter; Lakosi, Ferenc; Repa, Imre] Moritz Kaposi Teaching Hosp, Dr Jozsef Bake Diagnost Radiat Oncol Res & Teachi, Kaposvar, Hungary; [Sipos, David; Toth, Zoltan; Repa, Imre; Kovacs, Arpad] Univ Pecs, Doctoral Sch Hlth Sci, Pecs, Hungary; [Sipos, David; Kovacs, Peter; Tollar, Jozsef; Lakosi, Ferenc; Kovacs, Arpad] Univ Pecs, Dept Med Imaging, Fac Hlth Sci, Pecs, Hungary; [Toth, Zoltan] MEDICOPUS Healthcare Provider & Publ Nonprofit Lt, Somogy Cty Moritz Kaposi Teaching Hosp, Kaposvar, Hungary; [Tollar, Jozsef] Somogy Cty Moritz Kaposi Teaching Hosp, Dept Neurol, Kaposvar, Hungary; [Gulyban, Akos] Inst Jules Bordet, Med Phys Dept, Brussels, Belgium; [Kovacs, Arpad] Univ Debrecen, Fac Med, Dept Oncoradiol, Debrecen, Hungary in 2021.0, Cited 44.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Name: 1H-1,2,4-Triazol-5-amine
Purpose To investigate the added value of 6-(18F]-fluoro-L-3,4-dihydroxyphenylalanine (FDOPA) PET to radiotherapy planning in glioblastoma multiforme (GBM). Methods From September 2017 to December 2020, 17 patients with GBM received external beam radiotherapy up to 60 Gy with concurrent and adjuvant temozolamide. Target volume delineations followed the European guideline with a 2-cm safety margin clinical target volume (CTV) around the contrast-enhanced lesion+resection cavity on MRI gross tumor volume (GTV). All patients had FDOPA hybrid PET/MRI followed by PET/CT before radiotherapy planning. PET segmentation followed international recommendation: T/N 1.7 (BTV1.7) and T/N 2 (BTV2.0) SUV thresholds were used for biological target volume (BTV) delineation. For GTV-BTVs agreements, 95% of the Hausdorff distance (HD95%) from GTV to the BTVs were calculated, additionally, BTV portions outside of the GTV and coverage by the 95% isodose contours were also determined. In case of recurrence, the latest MR images were co-registered to planning CT to evaluate its location relative to BTVs and 95% isodose contours. Results Average (range) GTV, BTV1.7, and BTV2.0 were 46.58 (6-182.5), 68.68 (9.6-204.1), 42.89 (3.8-147.6) cm(3), respectively. HD95% from GTV were 15.5 mm (7.9-30.7 mm) and 10.5 mm (4.3-21.4 mm) for BTV1.7 and BTV2.0, respectively. Based on volumetric assessment, 58.8% (28-100%) of BTV1.7 and 45.7% of BTV2.0 (14-100%) were outside of the standard GTV, still all BTVs were encompassed by the 95% dose. All recurrences were confirmed by follow-up imaging, all occurred within PTV, with an additional outfield recurrence in a single case, which was not DOPA-positive at the beginning of treatment. Good correlation was found between the mean and median values of PET/CT and PET/MRI segmented volumes relative to corresponding brain-accumulated enhancement (r = 0.75; r = 0.72). Conclusion (18F)FDOPA PET resulted in substantial larger tumor volumes compared to MRI; however, its added value is unclear as vast majority of recurrences occurred within the prescribed dose level. Use of PET/CT signals proved to be feasible in the absence of direct segmentation possibilities of PET/MR in TPS. The added value of (18F)FDOPA may be better exploited in the context of integrated dose escalation.
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Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
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