In 2022,Wilson, Julie A.; Lin, Zi Jie; Rodriguez, Isabelle; Ta, Thong; Martz, Luke; Fico, Dominic; Johnson, Shanina S.; Gorden, John D.; Shelton, Kerri L.; King, Lauren B. published an article in Journal of Heterocyclic Chemistry. The title of the article was 《Synthesis, characterization, and antimicrobial activity of lipophilic N,N’-bis-substituted triazolium salts》.Electric Literature of C2H3N3 The author mentioned the following in the article:
A series of N,N’-bis-substituted triazolium salts I [X = Y = N, CH; R = R1 = Ph, 2-naphthyl, 3-phenylphenyl, quinolin-2-yl; R2 = Cl, Br] and II [R3 = Ph, 2-naphthyl, 3-phenylphenyl, quinolin-2-yl; R4 = Ph, 2-naphthyl, 3-phenylphenyl] were synthesized using 1H-1,2,4-triazole, 1H-1,2,3-triazole, and 1H-1,2,3-benzotriazole. Synthesized compounds I and II were tested for their antimicrobial activities against a panel of representative ESKAPE pathogens, which are common culprits of hospital-acquired bacterial infections. Compounds I [X = N, Y = CH, R = R1 = 2-naphthyl, R2 = Br] and II [R3 = R4 = 2-naphthyl] displayed significant antimicrobial activities against all pathogens including a vancomycin-resistant strain of Enterococcus faecium and a multidrug resistant strain of Acinetobacter baumannii. Furthermore, the structure activity relationship of N,N’-bis-substituted triazolium salts I and II revealed a potential selectivity of Gram-pos. or Gram-neg. bacteria based on the heterocycle center. Thus, N,N’-bis-substituted triazolium salts I and II exhibited potent antimicrobial properties against multiple ESKAPE bacterial pathogens which warrants a further investigation of their biol. activities. In the experimental materials used by the author, we found 1H-1,2,3-Triazole(cas: 288-36-8Electric Literature of C2H3N3)
1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Electric Literature of C2H3N3
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics