Wu, Shanchao published the artcileFrom Antidiabetic to Antifungal: Discovery of Highly Potent Triazole-Thiazolidinedione Hybrids as Novel Antifungal Agents, Quality Control of 86386-77-8, the publication is ChemMedChem (2014), 9(12), 2639-2646, database is CAplus and MEDLINE.
In an attempt to discover a new generation of triazole antifungal agents, a series of triazole-thiazolidinedione hybrids I [R = Ph, 2-BrC6H4, 4-ClC6H4, etc.] were designed and synthesized by mol. hybridization of the antifungal agent fluconazole and rosiglitazone (an antidiabetic). Most of the target compounds showed good to excellent inhibitory activity against a variety of clin. important fungal pathogens. In particular, compounds I [R = 2,4-Cl2C6H3], I [R = 2-furyl], I [R = 3-furyl] were highly active against Candida albicans, with MIC80 values in the range of 0.03-0.15 μΜ. Moreover, the last two compounds compounds were found to be effective against four fluconazole-resistant clin. isolates; these two compounds are particularly promising antifungal leads for further optimization. Mol. docking studies revealed that the hydrogen bonding interactions between thiazolidinedione and CYP51 from C. albicans are important for antifungal activity. This study also demonstrates the effectiveness of mol. hybridization in antifungal drug discovery.
ChemMedChem published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C11H8O3, Quality Control of 86386-77-8.
Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics