Research speed reading in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 288-36-8, name is 1H-1,2,3-Triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. 288-36-8
A solution of 2-bromo-3-thiophene carboxylic acid (1.50 g, 7.24 mmol) , 1H-1, 2, 3-triazole (0.600 g, 8.69 mmol) , potassium carbonate (2.00 g, 14.5 mmol) , and copper iodide (0.138 g, 0.724 mmol) in DMF (36.2 mL) was purged subsurface with nitrogen and heated at 75 for 96 h. The reaction was diluted with water, washed with ether, and acidified with conc. HCl. The acidic aqueous solution was extracted 3x with EtOAc and the combined organic fractions were washed with brine, dried over MgSO4, filtered, and concentrated in vacuo. The crude material was purified by silica gel column chromatography [0-70 (1acetic acid in EtOAc) in hexanes] , providing the title compound as a solid. LRMS m/z (M+H) 196.2 found, 196.1 required.
The catalyzed pathway has a lower Ea, but the net change in energy that results from the reaction is not affected by the presence of a catalyst. In my other articles, you can also check out more blogs about 288-36-8
Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott D.; LIVERTON, Nigel; LUO, Yunfu; (59 pag.)WO2016/101118; (2016); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics