The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone, is researched, Molecular C10H7F2N3O, CAS is 86404-63-9, about Structure-based design, synthesis, and antifungal activity of new triazole derivatives, the main research direction is triazole arylacetamide containing derivative preparation antifungal activity; mol docking CYP51 triazole derivative.Category: triazoles.
A series of new antifungal triazole derivatives containing an arylacetamide side chain were rationally designed and synthesized on the basis of the structural information of lanosterol 14-demethylase (CYP51). In vitro antifungal activity assay indicated that several compounds showed higher activity than fluconazole. Especially, compound I showed excellent inhibitory activity against Candida albicans and Cryptococcus neoformans (MIC = 0.0156 μg/mL), suggesting that it is a promising lead for the development of novel antifungal agents. The binding mode of compound I was investigated by flexible mol. docking. It interacted with CACYP51 through hydrophobic and van der Waals interactions.
There is still a lot of research devoted to this compound(SMILES：FC1=CC=C(C(CN2N=CN=C2)=O)C(F)=C1)Category: triazoles, and with the development of science, more effects of this compound(86404-63-9) can be discovered.
Reference:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics