Electric Literature of 7411-23-6, New discoveries in chemical research and development in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
10.71 g (50 mmol, 1 eq) of 3,5-dibromo-1,2,4-triazole, 27.22 g (120 mmol, 2.4 eq)4-amino-4′-nitrobiphenyl, 14.4 g (150 mmol, 3 eq)Sodium tert-butoxide was dissolved in 350 mL of toluene.Then 1.8 g (2 mmol, 0.04 eq) of tris(dibenzylideneacetone)dipalladium and 1.19 g (4 mmol, 0.08 eq) of 2-(di-tert-butylphosphine)biphenyl were added to the solution.The above mixed solution was refluxed under nitrogen for 12 h.After the reaction is completed, it is cooled to room temperature for filtration.The filtered solid was dissolved in 300 mL of a mixed solvent of acetone and dichloromethane.The organic layer was washed with 200 mL of a 5% aqueous hydrochloric acid solution.The organic layer was dried over anhydrous magnesium sulfate and concentrated.The obtained crude product was passed through a silica gel column.Purification yielded 18.6 g of intermediate.The yield is 75%,
The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.I hope my blog about 3,5-Dibromo-1H-1,2,4-triazole is helpful to your research.
Reference:
Patent; Fuyang Xinyihua Materials Technology Co., Ltd.; Wu Jingwei; Wang Zhanqi; Guo Linlin; Hong Haozhi; (15 pag.)CN106479518; (2018); B;,
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