Yuan, Shuo published the artcileBronsted acid-promoted ‘on-water’ C(sp3)-H functionalization for the synthesis of isoindolinone/[1,2,4]triazolo[1,5-a]pyrimidine derivatives targeting the SKP2-CKS1 interaction, Name: 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine, the main research area is trimethoxyphenyl triazolopyrimidinyl methyl isoindolinone preparation SKP2 CKS1 inhibition SAR.
An efficient Bronsted acid-promoted C(sp3)-H functionalization approach that enabled the rapid construction of biol. important isoindolinone/[1,2,4]triazolo[1,5-a]pyrimidine hybrids from 5-methyl-7-(2,4,6-trimethoxyphenyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 2-formylbenzoic acid and various anilines was reported. The title compounds were generated in high to excellent yields (up to 96%) regardless of the electronic nature and steric effects of the substituents. In this reaction, an isoindolinone scaffold, one C-C single bond and two C-N bonds were formed simultaneously with high atom economy. It was concluded that the Me group linked to the electron-deficient N-heterocycles was used as a new synthetic handle for late-state diversification and may have broad applications in the field of organic and medicinal chem. Besides, the title compounds exhibited promising activity against the SKP2-CKS1 interaction.
Chinese Chemical Letters published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 24415-66-5 belongs to class triazoles, name is 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine, and the molecular formula is C6H5ClN4, Name: 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine.
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics