Zhang, Jie-bing published the artcileSynthesis and antifungal activity of 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-(N-cyclopropyl-N-benzylamino)-2-propanols, SDS of cas: 86386-77-8, the publication is Yaoxue Shijian Zazhi (2009), 27(2), 107-110, database is CAplus.
Design and synthesis of triazole antifungal derivatives based on the structure of fluconazole were disclosed. The title compounds were prepared via N-benzylation of 3-(N-cyclopropylamino)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-propanol with 4-(bromomethyl)benzoates. Structures of all the synthesized compounds were confirmed by MS, 1H-NMR, et al. The antifungal activities were evaluated against the eight tested pathogenic fungi. All title compounds exhibited activity against fungi tested to some extent. Compounds I and some other tested compounds exhibited strong antifungal activities against eight fungi. It is concluded that a benzyl moiety with a group of shorter length substituted on 4-position is required for higher activity.
Yaoxue Shijian Zazhi published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C27H39ClN2, SDS of cas: 86386-77-8.
Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics