Zhao, Qing-jie published the artcileSynthesis of 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[(cyclopropyl)(benzyl)amino]-2-propanol derivatives and test of their antifungal activity, Quality Control of 86386-77-8, the publication is Dier Junyi Daxue Xuebao (2009), 30(2), 198-201, database is CAplus.
A method for the synthesis of the title compounds [i.e., α-[[(phenylmethyl)(cyclopropyl)amino]methyl]-α-(2,4-difluorophenyl)-1H-1,2,4-triazole-1-ethanol derivs] is reported here. A cyclopropyl group was introduced in order to study the antifungal activity of the compounds thus prepared The target compounds were characterized by NMR, MS, elemental anal. Eight fungi were used for in vitro anti-fungal test. The compounds thus prepared showed antifungal activity, especially to the deep infection fungi, and had an MIC value <0.125 μg/mL against Candida albicans (showing thus antifungal activity 4 times higher than that of fluconazole and similar to that of terconazole).
Dier Junyi Daxue Xuebao published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C13H16O2, Quality Control of 86386-77-8.
Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics