Zhao, Qingjie published the artcileSynthesis of α-(2,4-difluorophenyl)-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol analogs and derivatives and determination of their activity as antifungal agents, SDS of cas: 86386-77-8, the publication is Zhongguo Yaowu Huaxue Zazhi (2006), 16(3), 150-153, database is CAplus.
To study the effect of triazole derivatives with a side chain containing a 4-substituted-1-piperidinyl groups or a similar secondary amine on the antifungal activity of triazole compounds, nine title compounds were synthesized and determined by elementary anal., 1H-NMR and IR spectra. An example compound thus prepared was α-(2,4-difluorophenyl)-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol. The MICs of all the title compounds were determined by a method recommended by the national committee for clin. laboratory standards (NCCLS) using the RPMI 1640 test medium. All of the title compounds displayed potent antifungal activities to some extent. The activity of the two compounds were more than 4 times as high as that of fluconazole and itraconazole against Candida albicans in vitro. The stereochem. had important influence on the antifungal activities of the title compounds (no data).
Zhongguo Yaowu Huaxue Zazhi published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C13H12BClO3, SDS of cas: 86386-77-8.
Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics