Zhou, Guochuan published the artcileSynthesis and antifungal activity of 2-(2,4-difluorophenyl)-1-(4-alkylpiperazin-1-yl)-3-(1,2,4-triazol-1-yl)-2-propanol, Application In Synthesis of 86386-77-8, the publication is Huaxue Yanjiu Yu Yingyong (2003), 15(4), 521-523, database is CAplus.
Four 1-(4-R-piperazin-1-yl)-2-(2,4-difluorophenyl)-3-(1,2,4-triazol-1-yl)-2-propanol derivatives (I; R = Me, Et, sec-Bu, or cyclopentyl) were designed and synthesized by acylating 1,3-difluorobenzene with chloroacetyl chloride in the presence of AlCl3, substituting with 1,2,4-triazole in the presence of NaHCO3, reacting with trimethylsulfoxonium iodide in toluene-20% NaOH solution in the presence of cetyltrimethylammonium bromide at 60° for 3 h, salifying with methanesulfonic acid in Et acetate, and then ring opening with 1-R-piperazine in ethanol, and their antifungal activities in vitro were determined All title compounds exhibited mild activities against yeast.
Huaxue Yanjiu Yu Yingyong published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C12H9NO, Application In Synthesis of 86386-77-8.
Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics