Zhou, Xiaoyun’s team published research in Journal of Medicinal Chemistry in 57 | CAS: 377727-87-2

Zhou, Xiaoyun published the artcileSynthesis and Preclinical Evaluation of 2-(2-Furanyl)-7-[2-[4-[4-(2-[¹¹C]methoxyethoxy)phenyl]-1-piperazinyl]ethyl]7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine-5-amine ([¹¹C]Preladenant) as a PET Tracer for the Imaging of Cerebral Adenosine A_2A Receptors, Computed Properties of 377727-87-2, the publication is Journal of Medicinal Chemistry (2014), 57(21), 9204-9210, database is CAplus and MEDLINE.

2-(2-Furanyl)-7-[2-[4-[4-(2-[¹¹C]methoxyethoxy)phenyl]-1-piperazinyl]ethyl]7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine-5-amine [¹¹C]-3 ([¹¹C]Preladenant) was developed for mapping cerebral adenosine A_2A receptors (A_2ARs) with PET. The tracer was synthesized in high specific activity and purity. Tissue distribution was studied by PET imaging, ex vivo biodistribution (BD), and in vitro autoradiog. (ARG) experiments Regional brain uptake of [¹¹C]-3 was consistent with known A_2ARs distribution, with highest uptake in striatum. The results indicate that [¹¹C]-3 has favorable brain kinetics and exhibits suitable characteristics as an A_2AR PET tracer.

Journal of Medicinal Chemistry published new progress about 377727-87-2. 377727-87-2 belongs to triazoles, auxiliary class GPCR/G Protein,Adenosine Receptor, name is 2-(Furan-2-yl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine, and the molecular formula is C6H8O6, Computed Properties of 377727-87-2.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics