Synthetic Route of C2H3N3In 2020 ,《Precise Preparation of a High-Purity Key Intermediate of Tazobactam》 was published in Organic Process Research & Development. The article was written by Zhou, Yanan; Wu, Chengjun; Ma, Hongzhi; Chen, Jianchao; Sun, Tiemin. The article contains the following contents:
In situ IR was used to precisely prepare high-purity diphenylmethyl 6α-bromopenicillanate 8 (VIII), a key intermediate of tazobactam (I). 8 Was obtained when 6α-bromopenicillanic acid 2 (II) reacted with diphenyldiazomethane (DDM). 2 Is unstable and must therefore react immediately with DDM upon preparation DDM is also unstable. As DDM decomposes rapidly upon preparation, the DDM content cannot be precisely determined using high-performance liquid chromatog. (HPLC) or gas chromatog. (GC). Therefore, good yield and purity are difficult to obtain, resulting in large batch-to-batch variations (yield 69.3-82.8%, purity 89.8-98.4%) for 8. The developed preparation method for 8 involved the use of in situ IR to monitor the reaction process and achieved good results (82.7-83.1% yield and 97.3-98.5% purity). This method was also used to prepare the key intermediate for the synthesis of cephalosporin derivatives, which have high industrial value. In the experiment, the researchers used 1H-1,2,3-Triazole(cas: 288-36-8Synthetic Route of C2H3N3)
1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Synthetic Route of C2H3N3
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics